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The patients who will do best on these medications over the long term are those who use them within a framework that protects lean mass, supports metabolic health, and addresses the behavioural and physiological underpinnings of weight regain

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For oral semaglutide (Rybelsus), it must be taken on an empty stomach with a small sip of water and patients should wait at least 30 minutes before eating, drinking or taking other oral medicines

Emerging studies and clinical experiences reveal that the approach to discontinuation mattersa sudden stop often triggers rapid weight regain, but a gradual taper paired with sustained lifestyle and behavioral changes can lead to more stable outcomes